Abstract: Chile, like other Latin American countries, is characterized by an accelerated increase in dementia prevalence. Early diagnosis is crucial to develop appropriate interventions. However, a large proportion of the Chilean...
Read moreResearch Projects
FONDECYT 1210622 | Contribution of peripheral Tau aggregates to Alzheimer´s disease pathogenesis | 2021-2025
Abstract: Recent reports show that Tau aggregates present in the brain of transgenic mice and AD patients can accelerate Tau spreading and downstream pathological cascades when exogenously administered in animal models. This...
Read moreAnillo ACT210096 | Machine Learning for Mental Health: New Developments and Applications Using Multimodal Data | 2021-2024
Abstract:: The main goal of this proposal is to develop statistical/machine learning methodologies for the analysis of data with complex structures, based on the applied experience acquired in the development of...
Read moreFONDECYT 1200880 | Contribution of the Unfolded Protein Response Signaling to Retinal Neural circuits Function during Aging and Neurodegeneration | 2020-2024
Abstract: This project introduces an innovative concept, where the reduction of the buffering capacity of the ER proteostasis network, measured trough the UPR, alters retinal neural circuits during aging and neurodegeneration in...
Read moreAlzheimer’s Drug Discovery Foundation and Target ALS Foundation (US). R-202203-2023090 | Machine learning for the diagnosis and multimodal profile of neurodegenerative diseases based on miRNA circulating miRNA in Latin American population | 2022-2024
Abstract: The proposed approach involves the development of a low-cost non-invasive diagnostic tool for the detection and differentiation between patients with AD, FTD, and ALS. This diagnosis is based on the interpretation...
Read moreHealthy Longevity Global Grand Challenge – ANID NAM23I0096 | Identification and validation of novel cell-free DNA methylation-based biomarkers for diagnosis of Alzheimer’s disease and frontotemporal dementia progression in blood | 2023 – 2024
The main idea of this project is to develop a biomarker based on cell-free DNA methylation (cfDNAm) that can uniquely detect degeneration in specific brain regions in diseases like Alzheimer’s and frontotemporal...
Read moreIBRO Parenthood Grants | Peripheral tau aggregates in Alzheimers disease pathogenesis | 2023 – 2024
The project will determine the impact of blood Tau aggregates to induce AD neuropathology in the nervous system using transgenic mouse models. Additionally, the project includes translational research to define the seeding...
Read moreThe Bluefield Project to Cure Frontotemporal Dementia A140624 | Building Capacity for Frontotemporal Dementia Trials in ReDLat | 2023 – 2024
The major goal of this project is to enhance the ReDLat Consortium’s capacity to identify potential candidates for clinical trials focusing on progranulin haploinsufficiency. It aims to build research capabilities within selected...
Read moreNational Institutes of Health (NIH) R01AG075775 | An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populations | 2023 – 2028
Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are major causes of disability and death in the US and Latin America. Dementia prevalence is high among Latinos, the US’s fastest-growing minority, yet financial...
Read moreNational Institutes of Health (NIH) R01AG083799 | Circadian disturbance and dementia in Latin America | 2023 – 2028
Dementia and neurodegeneration increasingly affect individuals, particularly in Latin America, where circadian disturbances may play a key role in the development of Alzheimer’s (AD) and frontotemporal dementia (FTD). This project aims to...
Read moreFormer Projects
BrainLat Seed Grant | Transcriptomic characterization of circulating cell-free mRNA in Latin American patients with Alzheimer’s Disease and Frontotemporal Dementia | 2021
Abstract: Circulating cell-free nucleic acids have emerged as a promising methodology to study many diseases, and in particular, represent a unique opportunity for dementia research. This project will combine characterize cell-free mRNA...
FONDEF 20I10252 | An effective immunotherapy for the treatment of Alzheimer’s disease: a pre-clinical trial | 2020-2022
Abstract:. Our research has focused on understanding the mechanism that explains this mutual protection between cancer and AD, and to this end we developed an animal model. We found that the generation...
FONDECYT 1190958 | Cancer leaves a trait of diminished immune tolerance that protects from Alzheimer’s disease | 2019-2023
Abstract:: In this project we propose to study the role that immunity plays in the inverse relationship between AD and cancer. In recent years there has been important progress in the treatment...
FONDEF 20I10152 | Machine learning for the early diagnosis and multimodal profile of Alzheimer’s disease based on miRNA of circulating exosome | 2020-2022
Abstract:: Identifying new blood biomarkers to detect the risk to develop AD in the early stages is pivotal and necessary to i) carry out massive early diagnosis at low cost and ii)...
